Gloria Santos Reynolds started the ministry of Ray of Hope in the heart of the Amazon River Basin in Manaus, Amazonas, Brazil in 2002. The ministry has grown significantly since its founding. The ministry focuses on ministering to the physical, educational and spiritual needs of people in the interior communities of the Amazon River Basin, with an emphasis on special needs children and adults, orphans and widows, In addition, Ray of Hope provides assistance and support to jungle pastors and missionaries, donation of Bibles and supplies for churches and schools, and relief work in communities along the rivers, such as clean water projects, digging wells, and assistance in emergency situations.